Identification of origins of marker chromosomes using fluorescence in situ hybridization / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 415-419, 2013.
Article
de Zh
| WPRIM
| ID: wpr-237236
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To assess the value of fluorescence in situ hybridization (FISH) and bacterial artificial chromosome FISH (BAC-FISH) for the diagnosis for patients with marker chromosomes.</p><p><b>METHODS</b>Sixteen patients with marker chromosomes were analyzed with technologies including GTG-banding, Q-banding, multiplex FISH and BAC-FISH.</p><p><b>RESULTS</b>The marker chromosomes in the 16 patients were verified as der(Y) (2 cases), psu dic(Y) (1 case), psu dic(15) (1 case), dic(15) (1 case), del(Y) (1 case), r(X) (5 cases), i(14 or 22) (2 cases), i(18) (1 case).</p><p><b>CONCLUSION</b>FISH and BAC-FISH can both verify the origin of marker chromosomes and provide accurate information for the diagnosis and treatment of patients.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Marqueurs génétiques
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Aberrations des chromosomes
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Hybridation fluorescente in situ
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Diagnostic
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Génétique
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Maladies génétiques congénitales
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Méthodes
Type d'étude:
Diagnostic_studies
Limites du sujet:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2013
Type:
Article