Pharmacology research on PXR as a potential target in screening bioactive components of Chinese material medica / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3444-3449, 2015.
Article
Dans Chinois
| WPRIM
| ID: wpr-237691
ABSTRACT
Pregnane X receptor (PXR) is key transcription factors which mainly regulate the expression of CYP3A genes. At the molecular level, PXR has been revealed the protection mechanism of the body against xenochemicals and a major mode of the drug-drug interactions. Besides playing an important role in drug metabolism and interactions, PXR and its target genes also play an important role in maintaining normal physiological function and homeostasis. Therefore, it is necessary to study the regulation of PXR and its related pharmacological effects of TCM and natural products, and to provide new clues for the new pharmacological pathway.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Médicaments issus de plantes chinoises
/
Récepteurs aux stéroïdes
/
Expression des gènes
/
Évaluation préclinique de médicament
/
Génétique
/
Métabolisme
Type d'étude:
Etude diagnostique
/
Étude de dépistage
Limites du sujet:
Animaux
/
Humains
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2015
Type:
Article
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