Expression of androgen receptor isoforms in normal human prostate / 中华男科学杂志
National Journal of Andrology
; (12): 501-506, 2003.
Article
Dans Zh
| WPRIM
| ID: wpr-237989
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of androgen receptor (AR) isoforms in normal human prostate.</p><p><b>METHODS</b>Fourteen normal prostatic specimens from donors, aged 25 on average (21-28 yr), were analyzed by high resolution isoelectric focusing (IEF). The expression of AR isoforms was demonstrated in all 14 normal human prostatic tissues.</p><p><b>RESULTS</b>Four types of AR isoforms were detected with isoelectric point value at 6.5, 6.0, 5.8 and 5.3 in 14 prostatic specimens. Binding of 3H-dihydrotestosterone (DHT) to these four AR isoforms was inhibited by the addition of 100-fold excess of DHT and testosterone. No effect of progesterone, estradiol and diethylstilbestrol on tritiated hormone binding was observed.</p><p><b>CONCLUSIONS</b>There are four AR isoforms in normal human prostate. The expression of AR isoforms is different from one another.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Prostate
/
Récepteurs aux androgènes
/
Isoformes de protéines
/
Focalisation isoélectrique
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Point isoélectrique
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Métabolisme
Limites du sujet:
Adult
/
Humans
/
Male
langue:
Zh
Texte intégral:
National Journal of Andrology
Année:
2003
Type:
Article