Effects of quercetin and enalapril on amount of PDGF-B and VEGF-1 in kidney of diabetic rats / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 791-794, 2005.
Article
de Zh
| WPRIM
| ID: wpr-238340
Bibliothèque responsable:
WPRO
ABSTRACT
This study sought to assess the effects of Quercetin and Enalapril on urinary protein excretion and amount of platelet-derived growth factor-B (PDGF-B) and vascular endothelial growth factor-1 (VEGF-1) in renal tissue of diabetic rats. 29 streptozotocin-induced diabetic rats were divided into 3 groups, diabetic control group (group D, n=12); Enalapril group (group E, n=10); Quercetin group (group Q, n=7). In addition, there was one normal control group (group N, n = 5). The urinary protein excretion of 24 hours was measured at 4, 8, 12 weeks. All rats were sacrificed at 12 weeks. The amounts of PDGF-B and VEGF-1 in renal tissue were measured by immunohistochemical techniques. The 24-h levels of urinary protein excretion of D,Q and E groups were higher than that of N group; the level of Q, E groups were lower than that of D group; there was no difference between Q and E group. The expression levels of PDGF-B and VEGF-1 in renal tissue of D, Q, and E groups were significantly higher than that of N group the levels of Q and E groups were significantly lower than that of D group, no difference was found between Q and E group. The protective role of Quercetin and Enalapril in lowering urinary protein excretion may be related to the decreased amounts of PDGF-B and VEGF-1 in renal tissue.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacologie
/
Protéinurie
/
Quercétine
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Énalapril
/
Répartition aléatoire
/
Rat Wistar
/
Protéines proto-oncogènes c-sis
/
Facteur de croissance endothéliale vasculaire de type A
/
Diabète expérimental
/
Rein
Limites du sujet:
Animals
langue:
Zh
Texte intégral:
Journal of Biomedical Engineering
Année:
2005
Type:
Article