Investigation of B-cell activating factor in serum and cerebrospinal fluid of patients with neuromyelitis optical / 南方医科大学学报
Journal of Southern Medical University
;
(12): 380-383, 2015.
Article
Dans Chinois
| WPRIM
| ID: wpr-239173
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of B-cell activating factor (BAFF) in the serum and cerebrospinal fluid of patients with neuromyelitis optical (NMO).</p><p><b>METHODS</b>Clinical data were collected from 44 patients with NMO and 38 patients with multiple sclerosis (MS). Thirty healthy controls and 15 controls with noninflammatory neurological diseases were also recruited. The concentration of BAFF in the serum and cerebrospinal fluid were measured by enzyme-linked immunosorbent assay (ELISA).</p><p><b>RESULTS</b>The mean serum BAFF level was 250.2 ± 126.9 pg/ml in NMO patients, 249.6 ± 130.7 pg/ml in MS patients, and 222.9 ± 126.1 pg/ml in the control subjects, showing no significant difference among the 3 groups (P>0.05). The mean BAFF level in the CSF was significantly higher in NMO patients than in MS patients (525.8 ± 230.0 pg/ml vs 298.4 ± 141.9 pg/ml, P<0.05), and higher in MS patients than in the control subjects (141.4 ± 76.2 pg/ml, P<0.05). Both NMO and MS group showed a positive correlation between EDSS scores and CSF BAFF level. But in NMO patients, CSF BAFF level was not associated with AQP4-antibody titer.</p><p><b>CONCLUSION</b>BAFF in the CSF may be a useful biomarker for a differential diagnosis of NMO from MS and has an important value in evaluating the disease severity.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Sang
/
Test ELISA
/
Marqueurs biologiques
/
Études cas-témoins
/
Liquide cérébrospinal
/
Neuromyélite optique
/
Diagnostic différentiel
/
Facteur d'activation des lymphocytes B
/
Sclérose en plaques
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2015
Type:
Article
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