Detection of hepatitis E virus on a blood donor and its infectivity to rhesus monkey / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 13-15, 2004.
Article
Dans Chinois
| WPRIM
| ID: wpr-240525
ABSTRACT
<p><b>OBJECTIVE</b>To understand the infectivity and pathogenicity of the plasma of hepatitis E virus (HEV) viremia to primate animals.</p><p><b>METHODS</b>RNA fragment of HEV genotype IV was detected on one healthy donor who was positive for anti-HEV IgM and negative for anti-HEV IgG. Then 10 ml plasma from above donor was transfused to rhesus monkey to observe its infectivity and pathogenicity.</p><p><b>RESULTS</b>Acute hepatitis E was developed in rhesus monkey who accept HEV RNA positive plasma. It was confirmed by virological, immunological, biochemical and histopathological data.</p><p><b>CONCLUSION</b>Acute hepatitis E can be induced by plasma transfusion of HEV viremia, which indicate the possibility of transfusion transmitted hepatitis E</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Sang
/
Donneurs de sang
/
ARN viral
/
Maladie aigüe
/
Virus de l'hépatite E
/
Hépatite E
/
Réaction transfusionnelle
/
Macaca mulatta
Type d'étude:
Etude diagnostique
Limites du sujet:
Animaux
/
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Hepatology
Année:
2004
Type:
Article
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