Biosynthesis-based production improvement and structure modification of erythromycin A / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 939-954, 2015.
Article
Dans Chinois
| WPRIM
| ID: wpr-240574
ABSTRACT
Erythromycin A is a clinically important macrolide antibiotic with broad-spectrum activity. Its biosynthesis involves the formation of the 14-membered skeleton catalyzed by polyketide synthases, and the modification steps such as hydroxylation, glycosylation and methylation. Based on the understanding of the biosynthetic mechanism, it is reliable to genetically manipulate the erythromycin A-producing strain for production improvement and structure modification. In this paper, we reviewed the progress regarding erythromycin A in high-producing strain construction and chemical structure derivation, to provide insights for further development.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Glycosylation
/
Chimie
/
Érythromycine
/
Famille multigénique
/
Polyketide synthases
/
Hydroxylation
/
Métabolisme
/
Méthylation
/
Antibactériens
langue:
Chinois
Texte intégral:
Chinese Journal of Biotechnology
Année:
2015
Type:
Article
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