Effect of xinmaitong on wild-type p53 gene expression in rabbits with carotid endothelial injury / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 445-454, 2003.
Article
Dans Chinois
| WPRIM
| ID: wpr-240935
ABSTRACT
<p><b>OBJECTIVE</b>To explore the mechanism of prevention and treatment of post-PTCA restenosis with Xinmaitong (XMT).</p><p><b>METHODS</b>Rabbit carotid endothelial injury model was established using Fishman air drying method. Effect of XMT on model rabbits wild-type p53 gene expression was observed by tissue in situ hybridization.</p><p><b>RESULTS</b>p53 gene expression appeared on the 3 days after operation, enhanced on the 7 days, reached the peak on the 14th day, weakened on the 21th, and still showed on the 28th day. The strongest expression was shown in rabbits treated by XMT, second in those treated by Warfarin, and the weakest in the operated control group.</p><p><b>CONCLUSION</b>XMT could promote the high expression of wild-type p53 gene expression in rabbit with carotid endothelial injury, which is possibly one of the important mechanism of XMT in preventing and treating arterial restenosis.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pharmacologie
/
Médicaments issus de plantes chinoises
/
Endothélium vasculaire
/
Artères carotides
/
Protéine p53 suppresseur de tumeur
/
Resténose coronaire
/
Génétique
/
Phytothérapie
/
Métabolisme
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Chinese Journal of Integrated Traditional and Western Medicine
Année:
2003
Type:
Article
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