Microwave radiation decreases the expressions of occludin and JAM-1 in rats / 中华男科学杂志
National Journal of Andrology
;
(12): 10-13, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-241221
ABSTRACT
<p><b>OBJECTIVE</b>To explore the changes in the expressions of the tight junction related protein occludin and junctional adhesion molecule-1 (JAM-1) of the blood-testis barrier and their significance in rats after microwave radiation.</p><p><b>METHODS</b>Eighty male Wistar rats were exposed to microwave radiation with average power density of 0, 10, 30 and 100 mW/cm2 for five minutes, and dynamic changes in the expressions of testicular occludin and JAM-1 were observed by Western blot and image analysis at 6 h, 1 d, 3 d, 7 d and 14 d after the radiation.</p><p><b>RESULTS</b>There was a significant down-regulation in the expression of the occludin protein at 3 - 7 d, 6 h - 7 d and 6 h - 14 d (P < 0. 05), as well as in that of JAM-1 at 3 - 7 d, 1 - 7 d and 1-14 d (P < 0.05) after exposure to 10, 30 and 100 mW/cm2 microwave radiation.</p><p><b>CONCLUSION</b>The decreased protein expressions of occludin and JAM-1 may play an important role in the microwave radiation induced-damage to the blood-testis barrier.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Effets des rayonnements
/
Testicule
/
Barrière hématotesticulaire
/
Molécules d'adhérence cellulaire
/
Régulation négative
/
Rat Wistar
/
Occludine
/
Protéines membranaires
/
Métabolisme
/
Micro-ondes
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
National Journal of Andrology
Année:
2010
Type:
Article
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