The GATA family in reproduction / 中华男科学杂志
National Journal of Andrology
;
(12): 932-936, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-241227
ABSTRACT
The GATA family proteins are a group of zinc finger transcription factors that are expressed in human and mammalian animals and play an important role in mammalian organ morphogenesis, cell proliferation and sex differentiation. GATA-4 and GATA-6 have been identified in the ovaries and testes of humans, mice, pigs and chickens. GATA-4 contributes to fetal male gonadal development by regulating the genes that mediate Müllerian duct regression and the onset of testosterone production. GATA-4 and GATA-6 are localized in and regulate the function of the ovarian and testicular somatic cells of fetal mice, especially granulosa cells, thecal cells, Sertoli cells and Leydig cells. GATA-4 is also present in the germ cells of fetal and prepubertal mice.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Ovaire
/
Reproduction
/
Suidae
/
Testicule
/
Facteurs de transcription
/
Poulets
/
Embryologie
/
Classification
/
Facteur de transcription GATA-4
/
Facteur de transcription GATA-6
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
National Journal of Andrology
Année:
2009
Type:
Article
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