Experimental varicocele affects VEGF and Flt-1 protein expressions in the testis and epididymis of adolescent rats / 中华男科学杂志
National Journal of Andrology
;
(12): 488-492, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-241314
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of experimental left varicocele (ELV) on the vascular endothelial growth factor (VEGF) and its receptor fms-like tyrosine kinase-1 (Flt-1) proteins in the testis and epididymis of adolescent rats, and to find out the correlation of the two proteins with varicocele-induced male infertility.</p><p><b>METHODS</b>We established the ELV model in adolescent male SD rats, and detected the expressions of VEGF and Flt-1 proteins in the testis and epididymis by immunohistochemistry at 2 and 4 weeks after surgery.</p><p><b>RESULTS</b>Cell- and region-specific expressions of VEGF and Flt-1 were observed in the testis and epididymis of the ELV and control groups. Statistical analysis showed that, in comparison with the corresponding control groups, the 2- and 4-week ELV groups exhibited a notable increase in the VEGF protein expression in the hibateral testis and epididymis (P < 0.01, P < 0.05); the Flt-1 expression was obviously upregulated in the hibateral testis and epididymis of the 2-week ELV group (P < 0.01, P < 0.01), but remarkably reduced in the hibateral testis and left epididymis of the 4-week ELV group (P < 0.01, P < 0.05), with no statistic difference in the right epididymis (P > 0.05).</p><p><b>CONCLUSION</b>ELV can cause changes in the expressions of VEGF and Flt-1 proteins in the testis and epididymis of adolescent rats, and consequently affect spermatogenesis and spermiotelcosis, which may be one of the causes of varicocele-induced male infertility or subfertility.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Testicule
/
Varicocèle
/
Expression des gènes
/
Rat Sprague-Dawley
/
Récepteur-1 au facteur croissance endothéliale vasculaire
/
Facteur de croissance endothéliale vasculaire de type A
/
Modèles animaux de maladie humaine
/
Épididyme
/
Métabolisme
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
National Journal of Andrology
Année:
2009
Type:
Article
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