Pharmacokinetics of beta-asarone in rats / 药学学报
Acta Pharmaceutica Sinica
;
(12): 836-838, 2004.
Article
Dans Chinois
| WPRIM
| ID: wpr-241388
ABSTRACT
<p><b>AIM</b>To study the pharmacokinetics of beta-asarone in rats.</p><p><b>METHODS</b>The concentration of beta-asarone in serum and organs were measured by HPLC after i.g. administration, the pharmacokinetics was analyzed with DAS software regarding the organs as independent system.</p><p><b>RESULTS</b>The pharmacokinetics of beta-asarone can be described as first order process of one-compartment model. In the serum, T(1/2), Tpeak and Cmax were 54 min, 12 min and 3.19 mg x L(-1), respectively. The procedure in the organs was similar to that in serum.</p><p><b>CONCLUSION</b>The absorption, distribution and elimination of beta-asarone are very rapid, and it is easy to pass through blood brain barrier. Brain is an important organ of distributing of beta-asarone.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Plantes médicinales
/
Encéphale
/
Pharmacocinétique
/
Barrière hémato-encéphalique
/
Distribution tissulaire
/
Chimie
/
Administration par voie orale
/
Chromatographie en phase liquide à haute performance
/
Rat Sprague-Dawley
/
Racines de plante
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2004
Type:
Article
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