Virological characteristics of avian influenza A H7N9 virus / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 405-408, 2013.
Article
Dans Chinois
| WPRIM
| ID: wpr-241507
ABSTRACT
From February 2013, a novel avian influenza A H7N9 virus causing human infection with fatal outcomes has been identified in eastern China. This avian influenza A H7N9 virus is a triple reassortant of viruses that are avian-origin only and it is low pathogenic in poultry. Several characteristic amino acid mutations in HA and PB2 polymerase subunit (including G186V, Q226L and E627K substitution) have been found through sequence analysis, and these mutations probably facilitate binding to human-type receptors and efficient replication in mammals. Other mutations in NA, M2 and NS genes were also found. Although sustained human-to-human transmission has not been conclusively established, limited human-to-human transmission of the H7N9 virus remains possible. Intensified surveillance for the H7N9 virus in humans and animals is needed to answer questions about the viral origin, spread and potential threat.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Virus de la grippe A
/
Virologie
/
Oiseaux
/
Chine
/
Épidémiologie
/
Grippe humaine
/
Grippe chez les oiseaux
/
Génétique
/
Mutation
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
/
Humains
Pays comme sujet:
Asie
langue:
Chinois
Texte intégral:
Chinese Journal of Contemporary Pediatrics
Année:
2013
Type:
Article
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