Effect of ginseng-sanqi extract on the Ras associated signal proteins / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 802-805, 2009.
Article
de Zh
| WPRIM
| ID: wpr-242393
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effect of ginseng-sanqi extract (GSE) on the vascular endothelium growth factor receptor-2 (VEGFR-2), Ras and mitogen-activated protein kinase (MAPK) in VEGFR-2-Ras-MAPK signal pathway of angiogenesis in cultured human umbilical vascular endothelial cells (HUVECs).</p><p><b>METHODS</b>The protein expressions of VEGFR-2, Ras and MAPK in HUVEC and the effects of GSE (at different doses) and basic fibrin growth factor (bFGF) on them were detected by Western-Blot test.</p><p><b>RESULTS</b>GSE can enhance the expression of angiogenesis signaling proteins (VEGFR-2, Ras, MAPK) to different extents, especially in the groups treated by bFGF or higher dose GSE, the levels showed significant differences to those in the blank group (P<0.05).</p><p><b>CONCLUSION</b>GSE can promote the expressions of VEGFR-2, Ras and MAPK in the angiogenesis signaling pathway, which may be the foundation of Chinese medicine for tonifying qi and activating blood circulation in promoting endothelial proliferation and angiogenesis.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacologie
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Médicaments issus de plantes chinoises
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Transduction du signal
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Cellules cultivées
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Mitogen-Activated Protein Kinases
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Ginsénosides
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Récepteur-2 au facteur croissance endothéliale vasculaire
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Cellules endothéliales de la veine ombilicale humaine
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Métabolisme
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Chinese Journal of Integrated Traditional and Western Medicine
Année:
2009
Type:
Article