Detection of gene mutations of SCN5A in 7 patients with Brugada syndrome / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 404-407, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-243770
ABSTRACT
<p><b>OBJECTIVE</b>Brugada syndrome is linked to sodium channel mutations and could induce arrhythmias that even lead to sudden death. The purpose of this study was to detect if there was gene mutation of SCN5A in 7 patients with Brugada syndrome and explore the molecular genetic characteristics of this disease.</p><p><b>METHOD</b>Genomic DNA was extracted from peripheral blood of all 7 patients with Brugada syndrome and 41 pairs of PCR primers were designed to amplify all the 28 exons of SCN5A.</p><p><b>RESULT</b>There was no novel mutation in exons of Gene SCN5A in these patients with Brugada syndrome.</p><p><b>CONCLUSION</b>Brugada syndrome might associated gene mutation or other mechanisms independent of SCN5A gene mutation.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Analyse de mutations d'ADN
/
Canaux sodiques
/
Exons
/
Syndrome de Brugada
/
Génétique
/
Protéines du muscle
/
Mutation
Type d'étude:
Etude diagnostique
Limites du sujet:
Adulte
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Cardiology
Année:
2008
Type:
Article
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