Safety evaluation of niuhuang jiedu tablet / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 3221-3225, 2014.
Article
Dans Zh
| WPRIM
| ID: wpr-244591
Responsable en Bibliothèque :
WPRO
ABSTRACT
Realgar-containing Niuhuang Jiedu tablet (NHJD) has been applied in clinic for more than 800 years. However, because realgar contains arsenic (As), it has aroused wide concerns and controversies both at home and abroad. Currently, there are two misunderstandings about realgar-containing Chinese patent medicines. First, some people exaggerated realgar's toxicity as that of arsenic. Second, they recommended to remove realgar from traditional Chinese medicine compounds. In this paper, the authors summarized the advance in studies on NHJD, and proposed different opinions: (1) It is inappropriate to take total As as the index in safety evaluation of NHJD. (2) The toxicity of NHJD is dependent on the dose and duration of administration. (3) Realgar is an active ingredient of NHJD, and shall be deeply studied. Classic realgar-containing traditional Chinese medicine prescriptions, such as Niuhuang Jiedu tablet, shall be evaluated with rigorous modern scientific basis, with the aim to guide rational and safe application.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Composés de l'arsenic
/
Sulfures
/
Comprimés
/
Facteurs temps
/
Médicaments issus de plantes chinoises
/
Chimie
/
Chimie pharmaceutique
/
Résultat thérapeutique
/
Utilisations thérapeutiques
/
Relation dose-effet des médicaments
Type d'étude:
Diagnostic_studies
Limites du sujet:
Animals
/
Humans
langue:
Zh
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2014
Type:
Article