Epigenetics and cancer / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 1133-1136, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-244676
ABSTRACT
Epigenetic modifications, including DNA methylation, histone modifications, RNA epigenetics and nucleosome remodeling, are important for gene transcription, but such modifications do not change the coding sequence of the gene. Although these events are heritable, they are potentially reversible, thus opening up opportunities for the therapy of cancer. So epigenetic modifications have been thrusted into the forefront of new drug discoveries. Current knowledge suggests that the agents that intervene epigenetics by "turning back on" silenced genes may represent a significant advancement in treating many forms of cancer. In this review, we summarized the research progress of epigenetic gene regulation and the proteins which could read epigenetic codes. And the relationship between epigenetics and cancer was discussed comprehensively.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Thérapeutique
/
Histone
/
Régulation de l'expression des gènes
/
Méthylation de l'ADN
/
Épigenèse génétique
/
Génétique
/
Métabolisme
/
Tumeurs
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Biomedical Engineering
Année:
2009
Type:
Article
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