Design, synthesis and biological evaluation of fingolimod analogues containing diphenyl ether moiety / 药学学报
Acta Pharmaceutica Sinica
;
(12): 896-904, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-244997
ABSTRACT
A novel series of fingolimod analogues containing diphenyl ether moiety were designed and synthesized based on the modification of immunosuppressive agent fingolimod used in the treatment of multiple sclerosis. Compounds were evaluated in vivo for lymphopenic activity and heart rate affection. Most compounds showed moderate lymphopenic activity. It is worth noting that compounds 6c, 6d and 14c-14e showed considerable immunosuppressive activities comparable to fingolimod. And compound 14e had no effect on heart rate.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pharmacologie
/
Éthers phényliques
/
Relation structure-activité
/
Chimie
/
Chlorhydrate de fingolimod
/
Rythme cardiaque
/
Immunosuppresseurs
/
Lymphopénie
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2014
Type:
Article
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