Progress in research of the structural optimization of natural product-like Garcinia caged xanthones / 药学学报
Acta Pharmaceutica Sinica
; (12): 293-302, 2014.
Article
de Zh
| WPRIM
| ID: wpr-245086
Bibliothèque responsable:
WPRO
ABSTRACT
Designing of natural product-like compounds using natural products as template structures is an important strategy for the discovery of new drugs. Gambogic acid (GA), which is a Garcinia natural product with a unique caged xanthone scaffold, inhibits potent antitumor activity both in vitro and in vivo. This review summarized the researches on the identification of the antitumor pharmacophore of GA, and the design, structural optimization and structure-activity relationship (SAR) of natural product-like caged xanthones based on it.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacologie
/
Relation structure-activité
/
Produits biologiques
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Tests de criblage d'agents antitumoraux
/
Structure moléculaire
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Chimie
/
Garcinia
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Lignée cellulaire tumorale
/
Xanthones
/
Prolifération cellulaire
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2014
Type:
Article