Pathological characteristics and clinical significance of macrochilia secondary to venular malformation / 中华口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To analyze the histologic characteristics of macrochilia secondary to port-wine stain and to elucidate the possible mechanism.</p><p><b>METHODS</b>Twenty-one cases of macrochilia secondary to venular malformation were included and the histology of the lesions was observed by light microscope.</p><p><b>RESULTS</b>Histological examination revealed vascular abnormalities and a number of widely distributed hamartomatous changes in macrochilia secondary to venular malformation. The average vessel diameter is (39.8 +/- 15.7) microm. The degree of hamartomatous change mild (1 case), moderate (7 cases) and severe (13 cases).</p><p><b>CONCLUSIONS</b>The complex hamartomatous changes suggest a genetically determined, multilineage developmental field defect in the pathogenesis of venular malformation.</p>