Association of HLA-DQB1 alleles and dermatomyositis/ polymyositis / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate further the nature of HLA-DQB1 alleles association with dermatomyositis/polymyositis (DM/PM).</p><p><b>METHODS</b>HLA-DQB1 typing of 52 patients with DM/PM were investigated by polymerase chain reaction-sequence specific primer method, and the frequencies of HLA-DQB1 alleles were compared.</p><p><b>RESULTS</b>It was found that the patients with DM/PM had significantly increased frequency of HLA-DQB1*0401(RR=3.56, P=1.79 10(-3), Pc<0.05).</p><p><b>CONCLUSION</b>The results suggest that HLA-DQB1*0401 gene contribute to genetic susceptibility to DM/PM.</p>