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Protective action of effective components of Huanglian Jiedu decoction on hypoxia and reoxygenation injury in cultured rat cerebral microvascular endothelial cells / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 249-252, 2007.
Article Dans Chinois | WPRIM | ID: wpr-245997
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the protective effect of geniposide, baicalin and berberine for the rat cerebral microvascular endothelial cell.</p><p><b>METHOD</b>The model of hypoxia and reoxygenation injury in rat cerebral microvascular endothelial cells in vitro was established. Both normal and model cells were treated with geniposide (1.024, 0.512, 0.256, 0.128, 0.064, 0.032, 0.016, 0.008 micromol x mL(-1)), baicalin (0.224, 0.112, 0.056, 0.028, 0.014, 0.007, 0.003 micromol x mL(-1)) and berberine (0.192, 0.096, 0.048, 0.024, 0.012, 0.006, 0.003 micromol x mL(-1)). Cell activity was measured by methyl thiazolyl tetrazolium (MTT) test.</p><p><b>RESULT</b>After hypoxia/hypoglycemia cultures for 4 hour and reoxygenation for 12 hour, geniposide (0.128, 0.064, 0.032 micromol x mL(-1)), baicalin (0.028, 0.014, 0.007 micromol x mL(-1)) and berberine (0.024, 0.012, 0.006 micromol x microL(-1) could protect the injuried cerebral microvascular endothelial cells.</p><p><b>CONCLUSION</b>Appropriate concentration of geniposide, baicalin and berberine, which are effective components of Huanglian Jiedu decoction, could protect the injuried cerebral microvascular endothelial cells.</p>
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Oxygène / Pharmacologie / Plantes médicinales / Pyrannes / Berbérine / Flavonoïdes / Médicaments issus de plantes chinoises / Hypoxie cellulaire / Survie cellulaire / Cellules cultivées Limites du sujet: Animaux langue: Chinois Texte intégral: China Journal of Chinese Materia Medica Année: 2007 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Oxygène / Pharmacologie / Plantes médicinales / Pyrannes / Berbérine / Flavonoïdes / Médicaments issus de plantes chinoises / Hypoxie cellulaire / Survie cellulaire / Cellules cultivées Limites du sujet: Animaux langue: Chinois Texte intégral: China Journal of Chinese Materia Medica Année: 2007 Type: Article