The DNA metylation in vertebral animal: significant and modulation

ABSTRACT

Review of the process basing on DNA showed that the DNA metylation occurs highly and suddenly increase of the gene number during change from convertebrate animal to vertebrate animal. So DNA metylation Þ is considered as a basic of this evolution. The DNA metylation plays an important role in gene expression, fetal growth and tumor generation in vertebral animal. Today, it is identified that the DNA metylation occurs in the 5th position of cytosine (5mC) and the first enzyme contributes the process of DNA metylation is DNA metyltransferase (Dmt).