Effects of proton pump inhibitors on in-stent restenosis in patients receiving clopidogrel: a retrospective analysis / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 667-672, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-247195
ABSTRACT
<p><b>OBJECTIVE</b>To determine the effect of proton pump inhibitor (PPI) on in-stent restenosis (ISR) in patients receiving clopidogrel therapy.</p><p><b>METHODS</b>Total 439 patients underwent percutaneous coronary intervention (PCI) were enrolled in the study,including 250 post-PCI patients discharged on clopidogrel alone and 189 patients discharged on clopidogrel with PPI. The in-stent restenosis (ISR) ratio of the patients in these two groups were observed.</p><p><b>RESULTS</b>During a mean follow-up period of (13 ± 5.9) months, the post-PCI patients discharged on concomitant clopidogrel-PPI therapy had higher risk of ISR than those discharged on clopidogrel alone (19.6% Compared with 8%, P<0.001).</p><p><b>CONCLUSION</b>Concomitant use of clopidogrel and PPI after hospital discharge would increase the risk of ISR for post-PCI patients.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Ticlopidine
/
Antiagrégants plaquettaires
/
Angioplastie coronaire par ballonnet
/
Endoprothèses
/
Risque
/
Études rétrospectives
/
Études de suivi
/
Resténose coronaire
/
Utilisations thérapeutiques
/
Antagonisme des médicaments
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Zhejiang University. Medical sciences
Année:
2011
Type:
Article
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