Therapeutic effect of compound anisodine for primary open angle glaucoma / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the therapeutic effect of compound anisodine (CA) for patients with primary open angle glaucoma (POAG).</p><p><b>METHODS</b>According to the modified Hodapp-Parrish-Anderson Visual Fields Grading System, 46 patients with moderate stage POAG were randomized to receive compound anisodine injection (CA group) or venoruton tablets (control group). Visual acuity (VA), IOP, fundus, visual fields (VF) and the blood flow of optic nerve were observed.</p><p><b>RESULTS</b>The mean of defect (MD) was decreased in CA group after treatment. The PSV and EDV of ophthalmic artery were remarkably improved in both groups, as well as the PSV, EDV and RI of retinal central artery. Compound anisodine was superior in improving hemodynamics of ophthalmic artery and retinal central artery to venoruton.</p><p><b>CONCLUSION</b>Compound anisodine can protect optic nerve of POAG through improving the visual function and blood supply of optic nerve.</p>