Two Cases of Nephrolithiasis Following Administration of Cyclosporine / 대한신장학회지
Korean Journal of Nephrology
;
: 600-605, 2008.
Article
Dans Coréen
| WPRIM
| ID: wpr-24722
ABSTRACT
Cyclosporine is one of the most useful immunosuppressants for many diseases including nephrotic syndrome, glomerulonephritis, organ transplantation, and other autoimmune diseases. However, cyclosporine is known to cause renal tubular acidosis (RTA) due to a decrease in urinary ammonium excretion. Cyclosporine also can lead to significant hypocitraturia due to a higher proximal tubular reabsorption of citrate and increase the risk for nephrolithiasis. Citrate excretion is essential for the prevention of urinary supersaturation and hypocitraturia is a major risk factor for nephrocalcinosis and nephrolithiasis. Now we report two cases of nephrolithiasis treated with cyclosporine. The first patient is a renal transplantation recipient and the second patient has membranous glomerulonephritis. Therefore, these two cases lead us to conclude that patients treated with cyclosporine have to be regularly followed up for nephrolithiasis caused by cyclosporine-induced tubular dysfunction.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Maladies auto-immunes
/
Acidose tubulaire rénale
/
Glomérulonéphrite extra-membraneuse
/
Facteurs de risque
/
Transplantation d'organe
/
Transplantation rénale
/
Ciclosporine
/
Acide citrique
/
Transplants
/
Néphrolithiase
Type d'étude:
Etude d'étiologie
/
Facteurs de risque
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Nephrology
Année:
2008
Type:
Article
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