Prenatal diagnosis of Thailand deletion of alpha-thalassemia 1 / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 247-250, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-247342
ABSTRACT
<p><b>OBJECTIVE</b>To conduct prenatal diagnosis on the couples carrying Thailand deletion (--THAI) alpha-thalassemia 1 and at high risk of having fetus with alpha-thalassemia.</p><p><b>METHODS</b>Genotypes of couples and fetuses were analyzed by PCR and DNA sequencing.</p><p><b>RESULTS</b>Four pregnant women were patients with Hb H diseases of --THAI compounding with alpha-thalassemia 2, while their husbands were heterozygote of the Southeast Asian type alpha-thalassemia 1 (--SEA). Another 5 families, either husbands or wives were heterozygote of --THAI or --SEA. The genotypes of their fetuses were as follows 2 cases with Hb Bart's hydrops fetalis syndrome, 1 Hb H disease, 4 alpha-thalassemia heterozygote and 2 normal. The DNA sequencing approved the PCR results.</p><p><b>CONCLUSION</b>The study on prenatal diagnosis of Thailand deletion alpha-thalassemia 1 is of importance to the genetic counseling and prenatal diagnosis of alpha-thalassemia.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Diagnostic prénatal
/
Sang
/
Hémoglobines
/
Séquence nucléotidique
/
Délétion de séquence
/
Analyse de séquence d'ADN
/
Alpha-Thalassémie
/
Diagnostic
/
Maladies foetales
/
Génétique
Type d'étude:
Etude diagnostique
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
/
Grossesse
langue:
Chinois
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2007
Type:
Article
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