Study on the vertical transmission of Y chromosome microdeletions from father to son / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 203-205, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-247352
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the Y chromosome microdeletions in the family of the infertile male and to study on the vertical transmission of Y chromosome microdeletions from father to son.</p><p><b>METHODS</b>The peripheral blood of infertile patients' family male members was extracted and analyzed with modified multiplex PCR. The infertile family tree was drawn according to the results.</p><p><b>RESULTS</b>Two cases in twelve investigated families had azoospermia factor (AZFc) microdeletion heredity. The others had no heredity.</p><p><b>CONCLUSION</b>AZFc microdeletion of the Y chromosome can be transmitted to the male offspring naturally,and the same deletion can result in different phenotypes in different individuals.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pedigree
/
Santé de la famille
/
Délétion de segment de chromosome
/
Chromosomes Y humains
/
Azoospermie
/
Génétique
/
Infertilité masculine
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2007
Type:
Article
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