Study on dispersivity of baicalin solid dispersion by vibrational spectrometry / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the dispersivity of baicalin solid dispersion by Raman spectrometry and infrared spectrometry in order to obtain a new and simple method in examining the dispersivity of solid dispersion.</p><p><b>METHOD</b>Baicalin solid dispersion was prepared by solvent method. The Raman spectra, infrared spectra and X-ray powder diffraction patterns of crude baicalin, PVP K30, physical mixture, solid dispersion were acquired by Raman and Fourier transform infrared spectrometers and X-ray powder diffractometry. Then the spectra were compared with each other in order to find out the differences between baicalin solid dispersion and other materials.</p><p><b>RESULT</b>The result of Raman spectrometry was that amorphous baicalin presented in the solid dispersion, which was in agreement with that of X-ray powder diffractometry.</p><p><b>CONCLUSION</b>Raman spectrometry which is fast, direct and non-destructive is an ideal method for examining the dispersivity of solid dispersion.</p>