Phenylhexyl isothiocyanate (PHI) regulates histone methylation and acetylation and induces apoptosis in SMMC-7721 cells / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 209-212, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-247556
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of PHI on histone acetylation and methylation in hepatocellular carcinoma line SMMC-7721 cells.</p><p><b>METHODS</b>Apoptosis was measured by TUNNEL assay. Histone methylation and acetylation were detected by Western blot.</p><p><b>RESULTS</b>PHI inhibited cells growth and induced apoptosis. PHI treatment resulted in increased acetylation of histone H3 and H4 , elevated level of histone H3 lysine 4 methylation, and decreased level of histone H3 lysine 9 methylation.</p><p><b>CONCLUSIONS</b>PHI can modulate both histone acetylation and methylation, which could remodel chromatin structure. PHI may be a novel anticancer drug.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Acétylation
/
Histone
/
Apoptose
/
Isothiocyanates
/
Lignée cellulaire tumorale
/
Prolifération cellulaire
/
Métabolisme
/
Méthylation
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Hepatology
Année:
2010
Type:
Article
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