The spontaneous YMDD mutation rate in chronic hepatitis B patients / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 887-890, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-247634
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the spontaneous YMDD mutation rate.</p><p><b>METHODS</b>Serum samples collected from 196 untreated chronic HBV patients were detected by primer-specific real-time PCR.</p><p><b>RESULTS</b>Among 196 patients, spontaneous YMDD variants were detected in 21 subjects (20 YVDD mutants and 1 YIDD mutant). YMDD variants account for more than 50%, 25% to 50%, 9% to 25% of total virus load in 1, 5 and 15 patients, respectively. Gender, age, HBeAg status, serum viral load, the state of disease and duration of infection were not associated with spontaneous YMDD mutation. Genotype B had higher spontaneous YMDD rate than genotype C (20.00% vs 7.38%, x(2) = 6.28, P < 0.05).</p><p><b>CONCLUSION</b>Spontaneous YMDD variants exist in chronic hepatitis B patients, Genotype B is associated with higher spontaneous YMDD rate.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Virologie
/
Sang
/
ADN viral
/
Virus de l'hépatite B
/
Réaction de polymérisation en chaîne
/
Sensibilité et spécificité
/
Amorces ADN
/
Charge virale
/
Hépatite B chronique
/
Génétique
Type d'étude:
Etude diagnostique
Limites du sujet:
Adolescent
/
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Hepatology
Année:
2009
Type:
Article
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