Role of nitric oxide and molsidomine in the management of pulmonary hypertension in Takayasu's arteritis / 결핵
Tuberculosis and Respiratory Diseases
; : 964-972, 2000.
Article
Dans Ko
| WPRIM
| ID: wpr-24801
Responsable en Bibliothèque :
WPRO
ABSTRACT
We report three patients with pulmonary hypertension in Takayasu's arteritis, who showed long-term favorable response, clinically and hemodynamically, to the nitric oxide donor, molsidomine. In these patients, the inhaled nitric oxide was effective in reducing pulmonary artery pressure (PAP) and pulmonary vascular resistance (PVR) as was shown in the acute vasodilator response test using the invasive hemodynamic monitoring. Molsidomine (single oral dose of 4 mg) was also effective in reducing PAP and PVR in the acute test, but nifedipine was not. With 4 mg of molsidomine three times daily, their dyspnea, exercise capacity and hemodynamic parameters were improved. These favorable responses have lasted during the 1st and 3rd month follow-up in all patients.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Artère pulmonaire
/
Donneurs de tissus
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Résistance vasculaire
/
Molsidomine
/
Nifédipine
/
Études de suivi
/
Maladie de Takayashu
/
Dyspnée
/
Hémodynamique
/
Hypertension pulmonaire
Type d'étude:
Observational_studies
/
Prognostic_studies
Limites du sujet:
Humans
langue:
Ko
Texte intégral:
Tuberculosis and Respiratory Diseases
Année:
2000
Type:
Article