Dopamine beta hydroxylase gene polymorphism and Parkinson's disease / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 238-240, 2003.
Article
Dans Chinois
| WPRIM
| ID: wpr-248450
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation between the polymorphism of dopamine beta hydroxylase(DBH) gene and the susceptibility of Shanghai Chinese Han population to Parkinson's disease(PD).</p><p><b>METHODS</b>Association study was performed in 144 PD patients and 188 healthy control subjects matched for age, sex and origin. Polymorphism of DBH gene was analyzed with polymerase chain reaction-restriction fragment length polymorphism.</p><p><b>RESULTS</b>The allelic frequency of A2 allele of DBH gene was significantly higher in PD patients than in controls(P<0.01).The risk of suffering from PD increased (OR=1.82) in the individual with A2 allele. And the genotypic frequency of A2/A2 was significantly higher in PD patients(OR=2.11, P<0.01),too. On the other hand, the allelic frequency of A1 allele and the genotypic frequency of A1/A2 genotype of DBH gene in PD patients were significantly lower(A1 alleles OR=0.54, P<0.01; A1/A2 genotypes OR=0.45, P<0.01).</p><p><b>CONCLUSION</b>The polymorphism in DBH gene might play an important role in the susceptibility of Shanghai Chinese Han population to PD.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Maladie de Parkinson
/
Polymorphisme génétique
/
Polymorphisme de restriction
/
Chine
/
Prédisposition génétique à une maladie
/
Asiatiques
/
Dopamine beta-monooxygenase
/
Fréquence d'allèle
/
Génétique
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Asie
langue:
Chinois
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2003
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS