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Multi-center cross-sectional study on type-specific human papillomavirus infection among Chinese women / 中华流行病学杂志
Chinese Journal of Epidemiology ; (12): 1351-1356, 2015.
Article Dans Chinois | WPRIM | ID: wpr-248651
ABSTRACT
<p><b>OBJECTIVE</b>To study the type-specific prevalence of human papillomavirus (HPV) infection among women in China and to provide evidence for primary prevention and screening of cervical cancer programs.</p><p><b>METHODS</b>From May, 2004 to April, 2007, a population-based multicenter cross-sectional study was conducted by the Cancer Hospital, Chinese Academy of Medical Sciences. Women aged 17-59 years from 4 urban areas and 4 rural areas, were screened, under both liquid based cytological and HPV tests for cervical cancer. Specimens of cervical cell were used for genotyping with Linear Array or enzyme-linked immunesorbent assay. Women showed positive in primary screening were referred to exams for further colposcopy and/or histo-pathological detections.</p><p><b>RESULTS</b>A total of 6723 women were included in the data analysis. The overall prevalence of HPV infection was 15.5%. Two age-specific peaks of prevalence of HPV infection were detected among the different age groups. The first peak occurred in 17-24 year-old women in both rural areas and urban areas, while the second one occurred in 40-44 year-old women in urban areas and in 45-49 year-old women in rural areas. The prevalence of HPV infection increased with the severity of diagnosed cervical intraepithelial lesions by cytological or histo-pathological test (χ(2)=62.857, 22.113, P<0.001). HPV16 (3.2%) was seen the most common high risk HPV type, followed by HPV58 (1.8%) , HPV52 (1.5%) , HPV18 (1.0%) and HPV33 (1.0%) respectively. Other common types would include HPV66 (0.64%) , HPV42 (0.58%) and HPV53 (0.46%). The prevalence of HPV16 infection in rural women was significantly higher than that in urban women (χ(2)=4.696, P< 0.05).</p><p><b>CONCLUSION</b>Prevalence of HPV infection in Chinese women seemed to be high and with two age-specific peaks. HPV16 appeared the most commonly seen type in women with cervical lesions. HPV58 and 18 were the predominant types. Type-specific distribution of HPV infection should be taken into consideration in the development of comprehensive cervical cancer prevention strategies in China.</p>
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Papillomaviridae / Prévention primaire / Virologie / Tumeurs du col de l&apos;utérus / Chine / Santé en zone rurale / Santé en zone urbaine / Épidémiologie / Prévalence / Études transversales Type d'étude: Essai clinique contrôlé / Etude diagnostique / Étude observationnelle / Étude de prévalence / Facteurs de risque / Étude de dépistage Limites du sujet: Adolescent / Adulte / Femelle / Humains Pays comme sujet: Asie langue: Chinois Texte intégral: Chinese Journal of Epidemiology Année: 2015 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Papillomaviridae / Prévention primaire / Virologie / Tumeurs du col de l&apos;utérus / Chine / Santé en zone rurale / Santé en zone urbaine / Épidémiologie / Prévalence / Études transversales Type d'étude: Essai clinique contrôlé / Etude diagnostique / Étude observationnelle / Étude de prévalence / Facteurs de risque / Étude de dépistage Limites du sujet: Adolescent / Adulte / Femelle / Humains Pays comme sujet: Asie langue: Chinois Texte intégral: Chinese Journal of Epidemiology Année: 2015 Type: Article