Relationship between primary ocular adnexal mucosa-associated lymphoid tissue lymphoma and eye infection / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 513-518, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-249093
ABSTRACT
<p><b>OBJECTIVE</b>To study the role of pathogenic microorganisms commonly associated with chronic eye disease, including Chlamydia psittaci, Chlamydia trachomatis, Chlamydia pneumoniae, herpes simplex virus (HSV) type 1 and type 2, and adenovirus type 8 and type 19, in the development of primary ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma in Chinese patients.</p><p><b>METHODS</b>Sixty-eight archival cases of primary ocular adnexal lymphoproliferative lesions, including 38 cases of MALT lymphoma, 3 cases of non-MALT lymphoma and 27 cases of chronic inflammation, were enrolled into the study. DNA was extracted from the paraffin-embedded tissue samples. The presence of DNA of C. psittaci, C. trachomatis, C. pneumoniae, HSV type 1, HSV type 2, adenovirus type 8 and adenovirus type 19 were analyzed by multiplex touchdown enzyme time-release polymerase chain reaction (TETR-PCR).</p><p><b>RESULTS</b>All of the specimens yielded PCR products of over 100 base pairs and were thus suitable for TETR-PCR screening of infectious agents. The prevalence of DNA of C. psittaci, C. trachomatis and adenovirus type 19 were 0 in MALT lymphoma, non-MALT lymphoma and chronic inflammation. There were 2 cases positive for C. pneumoniae DNA, amongst the 38 cases of MALT lymphoma studied (5.3%, 2/38). HSV type 1, HSV type 2 and adenovirus type 8 DNA was found in each of the 3 patients with chronic inflammation.</p><p><b>CONCLUSION</b>The study indicates that C. psittaci, C. trachomatis, C. pneumoniae, HSV type 1, HSV type 2, adenovirus type 8 and adenovirus type 19 probably play little role in the pathogenesis of ocular adnexal MALT lymphoma in Chinese patients.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Psittacose
/
Virologie
/
ADN bactérien
/
ADN viral
/
Infections à Chlamydia
/
Infections de l'oeil
/
Infections humaines à adénovirus
/
Adénovirus humains
/
Chlamydophila psittaci
/
Chlamydia trachomatis
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Pathology
Année:
2009
Type:
Article
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