Expression of inducible nitric oxide synthase in cartilage in progression of temporomandibular joint osteoarthritis / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the expression of inducible nitric oxide synthase (iNOS) in cartilage of temporomandibular joint osteoarthriti (TMJOA), and to evaluate the role of iNOS in the progression of TMJOA.</p><p><b>METHODS</b>The goats were used and TMJOA was induced by injection of collagenase in upper joint space. The joints were obtained and were investigated by using immunohistochemistry at 2, 4, 12, 24 weeks after injection.</p><p><b>RESULTS</b>Almost no expression of iNOS in normal cartilage of TMJ. In the diseased joints, strong or definite iNOS reactivity was expressed.</p><p><b>CONCLUSION</b>iNOS plays an important role in the progression of TMJOA.</p>