Expression of core binding factor a1, bone morphogenetic proteins and osteopontin in the developing periodontal tissues of mice / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the expression and interaction of core binding factor a1 (Cbfa1), bone morphogenetic proteins (BMPs) and osteopontin (OPN) in the developing periodontal tissues of mice.</p><p><b>METHODS</b>A mice developing periodontal tissues study model was created histologically by 5-27 day postnatal BALB/c mice, then the immunohistochemical localization of Cbfa1, BMPs and OPN in different developing stages were undertaken.</p><p><b>RESULTS</b>In early stage of postnatal mice periodontal tissues development, only BMPs expressed in dental follicle cells, though the signal was weak. When root was forming, all of them were expressed in periodontal ligament cells and cementoblasts, while only OPN in acellular cementum, cellular cementum and the surface of alveolar bone, Cbfa1 only in cellular cementum and BMPs was seen in neither acellular cementum nor cellular cementum.</p><p><b>CONCLUSION</b>Cbfa1, BMPs and OPN all involve in the development of periodontal tissues, while OPN is crucial for cementum.</p>