Action of Schwann cells implanted in cerebral hemorrhage lesion / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 47-51, 2007.
Article
Dans Anglais
| WPRIM
| ID: wpr-249889
ABSTRACT
<p><b>OBJECTIVE</b>To investigate whether there is neogenesis of myelin sheath and neuron after transplantation of Schwann cells into cerebral hemorrhage lesion.</p><p><b>METHODS</b>Schwann cells were expanded, labeled with BrdU in vitro and transplanted into rat cerebral hemorrhage with blood extracted from femoral artery and then injected into the basal nuclei. Double immunohistochemistry staining and electron microscopy were used to detect the expression of BrdU/MBP and BrdU/GAP-43 and remyelination.</p><p><b>RESULTS</b>BrdU/MBP double positive cells could be seen at 1 week up to 16 weeks after transplantation of Schwann cells. Thin remyelination was observed under electron microscope. GAP-43 positive cells appeared after 12 weeks and were found more in Hippocamp.</p><p><b>CONCLUSIONS</b>Grafted Schwann cells participate in remyelination and promoter nerve restore in rat cerebral hemorrhage.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Cellules de Schwann
/
Nerf ischiatique
/
Thérapeutique
/
Transplantation
/
Hémorragie cérébrale
/
Embryologie
/
Rat Wistar
/
Protéine GAP-43
/
Biologie cellulaire
/
Métabolisme
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Biomedical and Environmental Sciences
Année:
2007
Type:
Article
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