Progress in the study of tubulin inhibitors / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1078-1088, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-250568
ABSTRACT
Microtubule is one of the key components of the cytoskeleton and plays an important role in the maintenance of cell shape and the process of signal transduction and mitosis. Due to the extreme importance of microtubule in the process of mitosis, tubulin becomes one of the most important targets for development of new anticancer drugs and tubulin inhibitors are used for the treatment of cancer nowadays. These inhibitors have antitumor activity by inhibiting or promoting the assembly of tubulin to microtubules and interfering the process of cell mitosis. This review summarized the research progress of the tubulin inhibitors, especially the introduction of the tubulin inhibitors of pharmacological activities and the progress of clinical research. Also, the development trend of these inhibitors is discussed.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Stilbènes
/
Relation structure-activité
/
Tubuline
/
Structure moléculaire
/
Chimie
/
Traitement médicamenteux
/
Modulateurs de la polymérisation de la tubuline
/
Métabolisme
/
Microtubules
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2010
Type:
Article
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