Synthesis and antidepressant activities of aryl alkanol piperidine derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 324-329, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-250584
ABSTRACT
To explore novel monoamine reuptake inhibitor with antidepressant activity, a series of substituted aryl alkanol piperidine derivatives were designed and synthesized. All of them were new compounds, and their structures were confirmed with 1H NMR and HR-MS. The results showed that compounds 4, 5 and 8 displayed strong 5-HT, NA and DA reuptake inhibiting activities in vitro. Among the tested compounds, 4, 5 and 13 exhibited potent antidepressant activities in the mice forced swimming test. Compounds 4 and 5 have potent antidepressant activities and are worth further development.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Pipéridines
/
Relation structure-activité
/
Natation
/
Synaptosomes
/
Structure moléculaire
/
Dopamine
/
Répartition aléatoire
/
Sérotonine
/
Norépinéphrine
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2010
Type:
Article
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