The function of protein kinase C in myocardial fibrosis / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1467-1471, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-250608
ABSTRACT
Myocardial fibrosis is the common results of the development of a variety of heart diseases which leads to extracellular matrix protein metabolic disorders and causes cardiac remodeling owing to cardiac fibroblasts proliferation, eventually results in malignant arrhythmia, heart failure, and even the occurrence of sudden cardiac death. Effective inhibition of myocardial remodeling could prevent the occurrence of sudden death. To know the protein kinase C (PKC) effective mechanism of regulation on myocardial fibrosis, a new therapeutic target for reversing myocardial remodeling might be provided.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pharmacologie
/
Fibrose
/
Protéine kinase C
/
Classification
/
Cardiomégalie
/
Remodelage ventriculaire
/
Matrix metalloproteinase 9
/
Indoles
/
Maléimides
Limites du sujet:
Animaux
/
Humains
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2010
Type:
Article
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