Development and validation of HPLC-UV-MS method for the control of four anti-diabetic drugs in suspected counterfeit products / 药学学报
Acta Pharmaceutica Sinica
;
(12): 347-352, 2010.
Article
Dans Anglais
| WPRIM
| ID: wpr-250651
ABSTRACT
An HPLC-UV method has been developed for the determination of valibose, miglitol, voglibose and acarbose, the four anti-diabetic drugs. The separation was accomplished successfully by using reversed phase chromatography (Prevail carbohydrate column, 250 mm x 4.6 mm, 5 microm) with a gradient acetonitrile-phosphate buffer solution (pH 8.0) at a wavelength of 210 nm. Furthermore, the method of a high-performance liquid chromatography coupled with ESI-MS in positive ionization mode has been established. These two methods were successfully applied to the assay and qualitative detection of four alpha-glucosidase inhibitors in the potential counterfeit anti-diabetic drugs.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Spectrophotométrie UV
/
Chimie
/
Chromatographie en phase liquide à haute performance
/
1-Désoxynojirimycine
/
Acarbose
/
Spectrométrie de masse ESI
/
Alpha-Glucosidase
/
Chromatographie en phase inverse
/
Inhibiteurs des glycoside hydrolases
/
Hypoglycémiants
Type d'étude:
Recherche qualitative
langue:
Anglais
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2010
Type:
Article
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