Relationship between interleukin-6 gene-572C/G polymorphism and chronic periodontitis / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 410-413, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-251043
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between interleukin-6 (IL-6) gene -572C/G polymorphism and the risk of chronic periodontitis disease.</p><p><b>METHODS</b>IL-6-572C/G genotype polymorphism was examined in 93 patients with chronic periodontitis and 96 control subjects by PCR restriction fragment length polymorphism (PCR-RFLP) method.</p><p><b>RESULTS</b>IL-6-572GG genotype and G allele were more frequent in chronic periodontitis patients than that in control subjects (P<0.05). -572CC, CG and GG genotype frequency were 52.7 % , 40.9 %, 6.4 % in chronic periodontitis patients and 67.7 %, 31.3%, 1.0 % in control subjects, respectively. -572CG + GG genotype and G allele were more frequent in patients than that in control subjects (P<0.05). Compared with CC genotype,the odds ratio for chronic periodontitis was 1.88 (95% CI 1.04-3.40, P<0.05) for CG + GG genotype.</p><p><b>CONCLUSIONS</b>The frequency of -572CG + GG genotype was higher in patients with chronic periodontitis compared with the control subjects. IL-6-572C/G polymorphism may be a genetic susceptibility factor for chronic periodontitis in Chinese Hans population.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Études cas-témoins
/
Interleukine-6
/
Prédisposition génétique à une maladie
/
Polymorphisme de nucléotide simple
/
Allèles
/
Parodontite chronique
/
Fréquence d'allèle
/
Génétique
/
Génotype
Type d'étude:
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Stomatology
Année:
2008
Type:
Article
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