Screening and analysis of multi-alleles in generalized aggressive periodontitis / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 406-409, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-251044
ABSTRACT
<p><b>OBJECTIVE</b>To detect the susceptible alleles in generalized aggressive periodontitis patients and healthy controls and to analyze the effect of multi-alleles on the occurrence and development of generalized aggressive periodontitis.</p><p><b>METHODS</b>Polymerase chain reaction and cleavage were used for detecting the frequencies of five susceptible genetic polymorphisms in generalized aggressive periodontitis patients and healthy controls. The results were analyzed by Z-score test and mean square analysis.</p><p><b>RESULTS</b>The frequencies of homozygous for HLA-DRB1* 1501 allele, TNF-A-308 allele II, IL-1B(+3953) allele II, vitamin D receptor allele A, T, estrogen receptor allele X in generalized aggressive periodontitis patients were higher than those in healthy controls. The persons who took more than three susceptible alleles (including three susceptible alleles) had more severe periodontal conditions than the ones who took less than three susceptible alleles (not including three susceptible alleles).</p><p><b>CONCLUSIONS</b>HLA-DRB1 * 1501 allele, TNFA-308 allele II, IL-1B(+3953) allele II, vitamin D receptor allele A, T, estrogen receptor allele X are susceptible alleles in generalized aggressive periodontitis. Carrying more than three susceptible alleles has a great effect on the occurrence and development of generalized aggressive periodontitis.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Parodontite agressive
/
Antigènes HLA-DR
/
Récepteurs des oestrogènes
/
Études cas-témoins
/
Facteur de nécrose tumorale alpha
/
Récepteur calcitriol
/
Prédisposition génétique à une maladie
/
Allèles
/
Interleukine-1 bêta
/
Chaines HLA-DRB1
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Étude de dépistage
Limites du sujet:
Adolescent
/
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Stomatology
Année:
2008
Type:
Article
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