Studies on the chemical constituents of the aerial part of Cimicifuga foetida L / 药学学报

ABSTRACT

<p><b>AIM</b>To look for new active constituents from the aerial part of Cimicifuga foetida L.</p><p><b>METHODS</b>Various column chromatographic techniques were used for the isolation and purification of the principles. The structures were elucidated on the basis of spectral data and chemical evidences.</p><p><b>RESULTS</b>Five 9,19-cycloartane triterpenoid saponins and one sitosterol saponin were obtained and identified as cimifoetiside I [12 beta-hydroxycimigenol-3-O-beta-D-galactoyranoside, (1)], cimifoetiside II [(23R,24R) cimigenol-3-O-beta-D-galactopyranoside, (2)], cimigenol-3-O-beta-D-galactopyranoside (3), 12 beta-hydroxycimigenol-3-O-beta-D-xylopyranoside (4), 12 beta-hydroxycimigenol-3-O-alpha-L-arabinopyranoside (5), daucosterol (6).</p><p><b>CONCLUSION</b>Compounds 1 and 2 are new and compounds 4 and 5 were isolated from this plant for the first time.</p>