Clinical and laboratory studies of 11 acute myeloid leukemia patients with t(7;11) (p15;p15) translocation / 中华血液学杂志
Chinese Journal of Hematology
; (12): 533-536, 2011.
Article
Dans Zh
| WPRIM
| ID: wpr-251494
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate clinical and laboratory characteristics of acute myeloid leukemia (AML) patients with t(7;11)(p15;p15).</p><p><b>METHODS</b>Eleven patients with t(7;11)(p15;p15) were retrospectively reviewed involved in cell morphology, immunophenotype, cytogenetics as well as clinical features and prognosis.</p><p><b>RESULTS</b>Eight patients out of the eleven were female, six patients were AML-M2a, two M4, two M5, and one M6. All the 11 cases expressed CD33, 10 expressed CD117 and CD13, HLA-DR and CD34 was expressed in 7 and 6 patients, respectively. Karyotypes of all the patients were t(7;11) (p115;p15), additional trisomy 8 were found in only one patient. FLT3-ITD was positive in one of nine patients who were analysed for FLT3-ITD and FLT3-TKD. Two patients were alive, and one lost to followed up, while the rest of eight were dead.</p><p><b>CONCLUSION</b>The t(7;11) (p15;p15) abnormalities is one of rare chromosomal translocation in patients with AML. AML patients with t(7;11) (p15;p15) have clinical features of anemia, thrombocytopenia, higher white blood cell, and poor prognosis.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pronostic
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Translocation génétique
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Chromosomes humains de la paire 7
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Chromosomes humains de la paire 11
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Leucémie aigüe myéloïde
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Études rétrospectives
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Diagnostic
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Tyrosine kinase-3 de type fms
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Caryotype
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Génétique
Type d'étude:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
Limites du sujet:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Chinese Journal of Hematology
Année:
2011
Type:
Article