Imatinib mesylate STI571 therapy for five patients with advanced gastrointestinal stromal tumors / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 129-131, 2005.
Article
Dans Chinois
| WPRIM
| ID: wpr-252454
ABSTRACT
<p><b>OBJECTIVE</b>To explore the therapeutic effect of STI571(imatinib mesylate) on advanced gastrointestinal stromal tumors (GISTs).</p><p><b>METHODS</b>Clinical data of 5 cases with advanced GISTs were analyzed retrospectively.</p><p><b>RESULTS</b>The expression of c- kit (CD117) was detected by immunohistochemical method in five patients with advanced GISTs . All patients failed to systematic chemotherapy or radiofrequency and operation because of extensive and multiple metastases (4 cases underwent 1 to 3 times of exploratory surgery). Tumor size was markedly decreased one to six months after STI571 given without serious drug- related side effects.</p><p><b>CONCLUSIONS</b>STI571 is an effective chemotherapy for advanced unresectable or metastatic GISTs. Inhibitor of the Kit signal- transduction pathway is a promising regimen that is different from conventional chemotherapy for advanced GISTs.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pipérazines
/
Pyrimidines
/
Benzamides
/
Études rétrospectives
/
Protéines proto-oncogènes c-kit
/
Utilisations thérapeutiques
/
Tumeurs stromales gastro-intestinales
/
Traitement médicamenteux
/
Mésilate d'imatinib
Type d'étude:
Étude observationnelle
Limites du sujet:
Adulte
/
Adulte très âgé
/
Aged80
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Gastrointestinal Surgery
Année:
2005
Type:
Article
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