Effect and mechnaisim of GLU and GABA in OFC on gastric motility / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>To Investigate the effect of glutamate (Glu) and gamma-aminobutyric acid(GABA) in orbitofrontal cortex (OFC) on regulation of gastric motility.</p><p><b>METHODS</b>Using microinjection in OFC,together with lesion of related nucleus,and recording the intragastric pressure(IGP).</p><p><b>RESULTS</b>(1) Microinjection of Glu in OFC caused a significant reduce of the amplitude of gastric motility, this effect could be reverse by lesion of amygdala, while lesion of LC had no influence on the effect of Glu. (2) microinjection of GABA in OFC could increase the amplitude of gastric motility significantly,and lesion of LC could abolish this effect,while lesion of amygdala could enhance the effect of GABA more.</p><p><b>CONCLUSION</b>Microinjection of Glu in OFC may enhance the normal inhibitory effect of amygdale on gastric motility, and the effect of microinjection of GABA in OFC on gastric motility is closely related with LC.</p>