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The relationship between the effects of curcumin on cerebral ischemia/reperfusion injury and immediately genic expressions of fos, Jun and NF-kappaB in hippocampal CA1 area and its significance in gerbils / 中国应用生理学杂志
Chinese Journal of Applied Physiology ; (6): 184-188, 2007.
Article Dans Chinois | WPRIM | ID: wpr-253451
ABSTRACT
<p><b>AIM</b>To explore the relationship between the effects of curcumin on cerebral ischemic/reperfusion injury and immediately genic expressions of Fos, Jun and NF-kappaB in hippocampal CA1 area.</p><p><b>METHODS</b>Gerbils were randomly divided into sham group (SH), ischemia/reperfusion group (I/R), curcumin group (CU) and solvent control group (SC). Forebrain ischemia was induced by occlusion of bilateral common carotid arteries. Observations were carried out in each group 15 min, 1 h, 2 h, 6 h, 1 d, 3 d, 5 d and 7 d after ischemia open field test was used to examine the behavioral change, the apoptosis neurons in hippocampal CA1 region was counted, the expression of Fos, Jun and NF-kappaB in hippocampal CA1 was detected by SABC immunocytochemical technique.</p><p><b>RESULTS</b>The behavioral mark and the number of apoptosis neurons in hippocampal (CA1 region was much less in CU group than in I/R group (P < 0.01) The expression of Fos was more and the expression of Jun and NF-kappaB was less in CA1 area in CU group than in I/R group (P < 0.01).</p><p><b>CONCLUSION</b>Curcumin can significantly protect neurons against cerebral ischemia, increasing the expression Fos and decreasing the expression of Jun and NF-kappaB may be the protective mechanisms.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Anatomopathologie / Pharmacologie / Lésion d&apos;ischémie-reperfusion / Encéphalopathie ischémique / Facteur de transcription NF-kappa B / Gerbillinae / Protéines proto-oncogènes c-jun / Protéines proto-oncogènes c-fos / Apoptose / Curcumine Limites du sujet: Animaux langue: Chinois Texte intégral: Chinese Journal of Applied Physiology Année: 2007 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Anatomopathologie / Pharmacologie / Lésion d&apos;ischémie-reperfusion / Encéphalopathie ischémique / Facteur de transcription NF-kappa B / Gerbillinae / Protéines proto-oncogènes c-jun / Protéines proto-oncogènes c-fos / Apoptose / Curcumine Limites du sujet: Animaux langue: Chinois Texte intégral: Chinese Journal of Applied Physiology Année: 2007 Type: Article