Synthesis and insulinotropic activity of 2-benzylidenesuccinic acid derivatives / 药学学报

ABSTRACT

<p><b>AIM</b>To design and synthesize new compounds of prandial glucose regulator with more simple structure.</p><p><b>METHODS</b>The target compounds were synthesized from diethyl succinate and benzaldehyde or 4-fluorobenzaldehyde by four-step reactions. Thus 18 compounds were synthesized. Their structures were comfirmed by NMR, MS and IR.</p><p><b>RESULTS</b>Seventeen compounds had different hypoglycemic activity in mice, among them, 9 compounds had higher hypoglycemic activity and 6 compounds had character of prandial glucose regulator.</p><p><b>CONCLUSION</b>Part of the compounds have higher hypoglycemic activity deserve to be further investigated.</p>